My wife and I are big advocates and supporters of animal shelters and pet rescues. Two we support in particular are located on the First Coast. One (which is organized and run by friends of ours, Janet Sydor and Gloria Conner of St. Augustine Florida) no longer has a dedicated web site but some information is available here.
We also support and volunteer for Pet Rescue North here in Jacksonville.
Both organizations are no kill shelters that are worthy of any support you can see fit to give them.